Job Description

We are seeking a highly motivated and experienced  Senior Scientist, In Vivo  to join our Preclinical Research team. The successful candidate will play a critical role in advancing our cell therapy programs for neurodegenerative diseases, with a primary focus on Parkinson’s disease. This position requires deep expertise in neuroscience, preclinical in vivo models, and hands-on experience with the 6-hydroxydopamine (6-OHDA) lesion model in nude rats .

Requirements

• Key Responsibilities:
• Design, execute, and analyze in vivo studies supporting the efficacy, safety, and mechanism-of-action of cell therapy candidates.
• Serve as subject matter expert on the 6-OHDA nude rat model for Parkinson’s disease; lead study design, dosing, behavioral assessments, and necropsy.
• Develop and refine animal models to evaluate neurodegeneration and cell therapy interventions.
• Collaborate cross-functionally with teams in cell biology, histology, and translational medicine to integrate data and interpret results.
• Ensure compliance with IACUC protocols and maintain high standards of animal welfare.
• Prepare and present data in internal meetings, author study protocols and reports, and author/review documents in support of regulatory filings.
• Qualifications:
• PhD in Neuroscience, Cell & Molecular Biology, or a related discipline, with 5+ years of postdoctoral or industry experience; MS with 8+ years or BS with 12+ years of relevant experience.
• Proven track record of leading in vivo studies for neurological disorders, particularly in Parkinson’s disease.
• Hands-on expertise with stereotaxic injections in rats is required, experience with 6-OHDA lesion model in nude rats preferred.
• Strong background in small animal surgery including immune-deficient rodents.
• Experience with animal behavioral assays.
• Excellent data analysis, scientific communication, and project management skills.
• Preferred Qualifications:
• Experience with human iPSC-derived cell therapies.
• Experience with histology, imaging and stereology techniques.
• Familiarity with regulatory requirements for IND-enabling studies.
• Experience with in vivo imaging.
• Prior industry experience in a biotech or pharmaceutical setting.

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