Senior Scientist, In vivo Job at Kenai Therapeutics, San Diego, CA

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  • Kenai Therapeutics
  • San Diego, CA

Job Description

We are seeking a highly motivated and experienced  Senior Scientist, In Vivo  to join our Preclinical Research team. The successful candidate will play a critical role in advancing our cell therapy programs for neurodegenerative diseases, with a primary focus on Parkinson’s disease. This position requires deep expertise in neuroscience, preclinical in vivo models, and hands-on experience with the 6-hydroxydopamine (6-OHDA) lesion model in nude rats .

Requirements

  • Key Responsibilities:
    • Design, execute, and analyze in vivo studies supporting the efficacy, safety, and mechanism-of-action of cell therapy candidates.
    • Serve as subject matter expert on the 6-OHDA nude rat model for Parkinson’s disease; lead study design, dosing, behavioral assessments, and necropsy.
    • Develop and refine animal models to evaluate neurodegeneration and cell therapy interventions.
    • Collaborate cross-functionally with teams in cell biology, histology, and translational medicine to integrate data and interpret results.
    • Ensure compliance with IACUC protocols and maintain high standards of animal welfare.
    • Prepare and present data in internal meetings, author study protocols and reports, and author/review documents in support of regulatory filings.
  • Qualifications:
    • PhD in Neuroscience, Cell & Molecular Biology, or a related discipline, with 5+ years of postdoctoral or industry experience; MS with 8+ years or BS with 12+ years of relevant experience.
    • Proven track record of leading in vivo studies for neurological disorders, particularly in Parkinson’s disease.
    • Hands-on expertise with stereotaxic injections in rats is required, experience with 6-OHDA lesion model in nude rats preferred.
    • Strong background in small animal surgery including immune-deficient rodents.
    • Experience with animal behavioral assays.
    • Excellent data analysis, scientific communication, and project management skills.
  • Preferred Qualifications:
    • Experience with human iPSC-derived cell therapies.
    • Experience with histology, imaging and stereology techniques.
    • Familiarity with regulatory requirements for IND-enabling studies.
    • Experience with in vivo imaging.
    • Prior industry experience in a biotech or pharmaceutical setting.

Job Tags

Full time,

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